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Image Search Results
Journal: PLoS ONE
Article Title: Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model
doi: 10.1371/journal.pone.0233962
Figure Lengend Snippet: (A) The ratio of Notch3IC cells to Control cells adhered to plates coated with indicated extracellular matrix. Dotted line indicates no change. Notch3IC cells display a significant increase in adherence to collagen I (p = 0.0118, Welch’s t-test) and collagen IV (p = 0.0163) and a small but significant reduction in adhesion to laminin (p = 0.0474). There is no significant difference in adhesion to fibronectin, vitronectin, or uncoated tissue culture dishes (p = 0.6237, p = 0.3075, p = 0.4206, Welch’s t-test). Sets #3–5 of ID8 IP2 were assessed in triplicate on 3 separate occasions. The Notch3IC mean was compared to the Control mean for each line. (B) Representative images of ID8 IP2 and Control cells adhered to collagen I-coated plates. (C) The ability of Notch3IC cells to collectively migrate into an open wound area is significantly reduced on collagen I (p = 0.0432, p = 0.0181 for 6 and 12 hours respectively) and fibronectin (p = 0.0004, p = 0.0020 for 6 and 12 hours respectively), but not on uncoated tissue culture dishes (p = 0.5422, p = 0.9637 for 6 and 12 hours respectively). Sets #3-#5 were assessed in quadruplicate wells twice. Graphs display the average of the duplicate experiments for each set. (D) The ability of Notch3IC cells to invade through insert pores coated with Collagen I, coated with Matrigel GFR, or uncoated was not significantly changed relative to Controls (p = 0.5634, p = 0.6076, and p = 0.1205, respectively). Sets #3-#5 of ID8 IP2 were assessed in triplicate wells and each set was averaged.
Article Snippet: We investigated migration by growing Notch3IC and Control cells on
Techniques:
Journal: Molecular cell
Article Title: HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
doi: 10.1016/j.molcel.2020.04.031
Figure Lengend Snippet: KEY RESOURCES TABLE
Article Snippet:
Techniques: Recombinant, Polymerase Chain Reaction, Gel Extraction, Plasmid Preparation, Transfection, Software, Protease Inhibitor, Cell Culture